Midtown’s tallest-ever skyscraper, to be anchored by Ken Griffin’s financial companies, has gotten the green light in a 48-0 vote by the City Council — a rare unanimous endorsement by the often development-averse body.

The plan for a new 350 Park Ave. represents a remarkable personal commitment by mega-billionaire Griffin, who’s a partner with two major development companies — privately held Rudin and publicly traded Vornado Realty Trust.

The 1,600-foot-tall tower will dwarf Midtown’s current cloudbuster king, the JPMorgan Chase headquarters at 270 Park Ave., by 200 feet. Its 1.7 million square feet of floor space will be anchored by two Griffin-owned companies, Citadel and Citadel Securities, which will occupy 850,000 square feet.